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As granulomas mature, they develop fibrous walls and experience a significant decrease in the number of vessels penetrating the structure, which hampers the penetration of anti-TB drugs into the necrotic and hypoxic areas of the granuloma, where M.tb persists [98, 99]

In addition, cerebral inflammation is known to be a key component of some neurologic diseases including Alzheimers disease, multiple sclerosis, and migraine (19)

Cell 182 , 15601573.e13 (2020)

PtGSTU19 and PtGSTU20 differ by a single amino acid between residues 34 and 51 (Ala 37 and Thr 37 in PtGSTU19 and 20, respectively)

In humans, SELENOW is expressed in numerous tissues, with highest levels found in skeletal muscle and heart (17)