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Both mechanisms are plausible antifibrotic targets in NASH, as the activation of HSCs the proliferation of myofibroblasts depend on those processes

J., Zeuzem, S

Tato I, Bartrons R, Ventura F, Rosa JL

In other highly proliferative normal cells like T cells, increased cytosolic acetyl-CoA levels are required for histone acetylation to promote interferon- (IFN) production 22