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Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed

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Athletes subject to drug testing should be aware that use could result in positive tests and associated consequences

It functions by blocking an enzyme known as nicotinamide N-methyltransferase (NNMT), which is important for how the body stores fat and uses energy

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Retatrutide is an investigational GLP-1, GIP, and glucagon triple receptor agonist currently in Phase 3 trials