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M., Coppotelli, G., Hoffer, B

doi: 10.1016/j.jhep.2020.06.006 32 KaufmannS

The principle of using mAbs to increase IgG catabolism was also demonstrated in NHPs, when Nixon and colleagues at Dyax Corp used phage-display selected human IgG1 mAbs with high pH-independent affinity towards FcRn to reduce circulatory IgG without affecting albumin levels in NHPs [122]