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10.2337/dc09-2124 250 SeixasJ

Sirtuin 1 (SIRT1) and the insulin-like growth factor receptor (IGFR) are among the most pharmacologically relevant, although not exhaustive, examples of stimulators of the HSF1HSP70 axis (Vihervaara and Sistonen, 2014

Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)

They look across multiple unconnected sources (unconnected is important, so youre not just stuck in an echo chamber) and see how many voices might be saying the same thing