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Thompson, D.H

For example, platinum (IV) prodrugs activated by intracellular GSH have demonstrated enhanced tumor selectivity and reduced systemic toxicity in clinical trials

Your body then has to put it back together, which is an inefficient process

doi: 10.1186/s40164-022-00344-4 237 ZhouWLiuHYuanZZundellJTowersMLinJet al

During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]