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JA, VF-S, and JJ: critical revision of the manuscript for important intellectual content

This binding switches 15LO1s preferred substrate from free arachidonic acid to arachidonic acid conjugated to PE, which generates ferroptotic lipids, including the hydroperoxy-phospholipid 15-hydroperoxy-eicosatetraenoic acidPE (15-HpETE-PE) (6, 7, 10, 13)

Whats happening: Your body is operating with robust antioxidant reserves

There are a few slight differences in doing the purification with each type of bead, however

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