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doi:10.1016/0006-291x(73)91459-9 Pickart L, Vasquez-Soltero JM, Margolina A

Taking care of physical health supports mental well-being

For the separate question of whether the sleep effect holds up at all as distinct from this articles question of what was dosed see our companion review, does DSIP improve sleep in the research literature

Recovery is structured: non-weightbearing for eight weeks while incisions heal, progressive transition to a total contact cast, protected weightbearing in a CROW boot from weeks eight through sixteen, custom diabetic footwear by months four to six when imaging confirms fusion, and a twelve-month benchmark for full recovery

Frequency: one subcutaneous injection each day at a consistent time, titrating up as tolerated over a 12-week cycle