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Endocrine and neuroendocrine mechanisms further contribute to the bidirectional communication between the gut and the brain (23)

Data accessibility : All data generated or analysed during this study are available from the corresponding author on reasonable request

Studies have indicated that the shelf-life of shiitake mushrooms varies depending on storage conditions: approximately 1 to 3 days at room temperature (20 to 25C), 5 to 7 days at 0 to 2C, and around 8 days under refrigeration (7)

These nanoformulations (e.g., liposomes, polymeric NPs) not only enhance pharmacokinetics but also actively modulate the tumor microenvironment (TME) by inhibiting myeloid-derived suppressor cells (MDSCs) and cancer-associated mesenchymal stromal cells (MSCs) [76, 77]

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Although the promising results derived from animal model studies are noteworthy, it is crucial to acknowledge that these outcomes may not necessarily be extrapolated seamlessly to humans due to inherent biological differences