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Conversely, excessive SAM accumulation without sufficient GSH conversion may promote ROS generation and activate the NLRP3 inflammasome, leading to IL-1 secretion (67)

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doi: 10.1038/s41596-019-0133-y 20 ChenRFultonKMTwineSMLiJ

247 Clinical data show that Met levels are reduced in the early stages of NAFLD and that higher Met intake is inversely associated with fibrosis risk

On the other hand, a lower dose delivered through a highly bioavailable format can be much more effective