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Some intestinal diseases, such as inflammatory bowel disease (IBD) or irritable bowel syndrome, can change the composition of the intestinal microbiota and affect the homeostasis of the intestinal carnitine pool

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Fifth, due to lack of reported data, we could not analyze the dietary patterns, medication usage, gut microbiome profiles, L-carnitine bioavailability, or skeletal muscle carnitine content of the patients included in this meta-analysis, which may have had differential effects on the metabolism of L-carnitine

However, whether these factors are causally related to CAD has been questioned in MR studies [45, 46], and we found no difference by sex in the risk factors

10.1016/j.actbio.2019.06.023 98 LinC

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