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Rojo de la Vega, M., Chapman, E

Indole-3-acetic acid (IAA), produced by gut microbiota, alleviates fibrosis by suppressing PI3K/AKT/mTOR signaling, enhancing autophagy, and reducing fibroblast activation and epithelial senescence [114]

Meanwhile, an in vitro study also showed that combination of LPS and (1 3)--D-glucan increased expression of IL-6 and TNF- in supernatant of HK-2 cells and upregulation expression of genes including Dectin-1 and Toll-like receptor 4, which promote inflammatory and fibrotic processes [121]

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Respir Res 2001, 2: 3346

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