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References : Perkins et al (2018)

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1 Introduction Autoimmune diseases are a heterogeneous group of disorders caused by the misdirection of the immune system toward its host, and the presence of autoantibodies is a common feature of autoimmune diseases ( Given the limited understanding of the complex molecular mechanisms underlying autoimmune diseases, it is widely accepted that a combination of genetic predisposition and environmental factors disrupts immune tolerance (6), This disruption leads to the clonal expansion of autoreactive B and T cells, resulting in the production of autoantibodies that trigger autoimmune inflammation and the pathological attack on the bodys tissues

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