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To improve strategies aimed at reinvigorating exhausted CD8 + T cells, including anti-PD therapy, defining the developmental biology of exhausted CD8 + T cells and determining which T-cell cluster primarily responds to anti-PD therapy are particularly important

Wu R, Huang Q, Zhou Z, Chen Y, Hu H, Wang F, et al

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The ketone ester, 3-hydroxybutyl-3-hydroxybutyrate, attenuates neurobehavioral deficits and improves neuropathology following controlled cortical impact in male rats

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MG therapy should be ambitious and aim for clinical remission or only mild symptoms with near-normal function and quality of life