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rxlist.com (Tofranil ) Keywords Mixed Direct & Indirect Acting Sympathomimetic Ephedrine Trade Name: generic Drug Class: Direct & Indirectly acting Sympathomimetic Mechanism of Action: Indirect Release of Presynaptic Norepinephrine : Although ephedrine has agonist properties on alpha and beta receptors, its primary mode of action is achieved by its indirect tyramine-like mechanism to displace norepinephrine from storage vesicles (Solanki et al, 2014

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In rats, long-term low-dose PS-NPs exposure reduced amygdalar metabolites-N-acetylserotonin, N-acetyl-L-tyrosine, and 4-aminobutyric acid, suggesting impaired neurotransmitter metabolism (Jiang et al., 2023)

[0021] The use of toothpaste formulations in accordance with the invention has other advantages as well